Teva SICOR Pharmaceuticals Inc, Irvine, CA. Marqibo (VinCRIStine Sulfate Liposome Injection) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Some side effects may not be reported. Check with your doctor immediately if any of the following side effects occur: Check with your doctor as soon as possible if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. After treatment with vincristine has ended, or sometimes even during treatment, normal hair growth should return. Side effects following the use of vincristine are dose related. Vincristine is … These are generally milder than those listed above and include: 1. This medicine often causes a temporary loss of hair. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, New Year Special -  40% off – Mayo Clinic Diet Online, dizziness or lightheadedness when getting up from a lying or sitting position, hallucinations (seeing, hearing, or feeling things that are not there). Side Effects See also Warning section. Local injection of hyaluronidase and the application of moderate heat to the area of leakage help disperse the drug and are thought to minimize discomfort and the possibility of cellulitis. Common and Rare Side Effects Along with their needed effects, medicines like vincristine can sometimes cause unwanted effects such as blood problems, nervous system problems, loss of hair, and other side effects. Severe symptoms may occur in 2 Reactions At The Site Of The Injection If experienced, these tend to have a Less Severe expression 1. "Product Information. If you notice any other effects, check with your healthcare professional. What else do I need to know? You may report side effects to the FDA at 1-800-FDA-1088. 1. Low Levels Of White Blood Cells 5. Some of these may be serious and must be reported to your doctor. Peripheral Sensory Nerve Disorde… Portions of this document last updated: Oct. 01, 2020. The most common adverse reaction is alopecia; the most troublesome adverse reactions are neuromuscular in origin.[Ref]. You should not use this medication if you have a nerve-muscle disorder, such as Charcot-Marie-Tooth syndrome, myasthenia gravis, ALS (Lou Gehrig's disease), multiple sclerosis , or muscular dystrophy. This site complies with the HONcode standard for trustworthy health information: verify here. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. It is common for people to experience some side effects in receiving this drug, but not everybody will experience side effects. © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). Vincasar PFS (vinCRIStine)." Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Medically reviewed by Drugs.com. The most common adverse reactions that have been reported include gastrointestinal toxicity, peripheral neuropathy, electrolyte abnormalities, cranial neuropathy and seizures. For intravenous use only; fatal if given by other routes. The use of small amounts of this drug daily for long periods is not advised. In children under 13 years of age, death has occurred following doses of vincristine that were 10 times those recommended for therapy. Along with their needed effects, medicines like vincristine can sometimes cause unwanted effects such as blood problems, nervous system problems, loss of hair, and other side effects. Disorientation 3. [Ref], Frequency not reported: Depression, agitation, insomnia, hallucinations[Ref], In general, adverse reactions are reversible and are related to dosage size and cumulative dosage. An Increase In Uric Acid Due To Cancer Chemotherapy 3. There are several things you can do to prevent or relieve constipation. A Disorder With Excess Antidiuretic Hormone Called Syndrome Of Inappropriate Antidiuretic Hormone 2. Applies to vincristine: compounding powder, intravenous solution, Frequency not reported: Acute shortness of breath, severe bronchospasm, dyspnea[Ref], Common (1% to 10%): Constipation (may take the form of upper colon impaction), paralytic ileus, abdominal cramps, Uncommon (0.1% to 1%): Nausea, vomiting, diarrhea, anorexia, stomatitis, oral ulceration, intestinal necrosis and/or perforation, abdominal cramps, abdominal distension, weight loss, Frequency not reported: Paralytic ileus (particularly in young children and in the elderly), pancreatitis[Ref], Frequency not reported: Anemia, leukopenia, thrombocytopenia[Ref], Frequency not reported: Hypertension, hypotension[Ref], Frequency not reported: Transient cortical blindness, optic atrophy with blindness, diplopia, ptosis, photophobia, visual hallucinations[Ref], Frequency not reported: Polyuria, oliguria, nocturia, dysuria, urinary retention, testicular pain[Ref], Frequency not reported: Second malignancies[Ref], Rare (0.01% to 0.1%): Allergic-type reactions (e.g., anaphylaxis)[Ref], Frequency not reported: Hepatic veno-occlusive disease, hepatitis[Ref], Frequency not reported: Neurotoxicity is the most common dose-limiting side effect of this drug. Forty patients with Non-Hodgkin's Lymphoma treated with vincristine between 1984 and 1990 (cumulative dose 12 mg in 18-24 weeks) were investigated in order to evaluate the long term effects of vincristine on the peripheral nervous Consumer information about the medication VINCRISTINE - INJECTION (Oncovin), includes side effects, drug interactions, recommended dosages, and storage information. Other effects, such as hair loss, … Since the growth of normal body cells may also be affected by vincristine, other effects will also occur. Numbness 6. In case of a severe side effect or reaction, call the doctor, nurse, or pharmacist at 595-3300. Other side effects not listed may also occur in some patients. Vincristine, a chemotherapeutic agent, in combination with azole antifungals, has shown to increase adverse drug reactions. If these happen, talk with your doctor about ways to lower these side effects. Discuss these possible effects with your doctor. constipation fatigue (feeling tired) peripheral neuropathy (weakness, numbness, and pain Commonly it causes a change in sensation, hair loss, constipation, difficulty walking, and headaches. Vincristine Sulfate Side Effects See also Warning section. With continued treatment, neuritic pain and later, motor difficulties may occur. : Vincristine stops the formation of microtubules, which are important in cell division (leading to nausea, low blood counts, hair loss, etc.) Most people experience some side effects from vincristine treatment. Check with your doctor immediately if any of the following side effects occur while taking vincristine: Check with your doctor as soon as possible if any of the following side effects occur while taking vincristine: Some side effects of vincristine may occur that usually do not need medical attention. Nausea, vomiting, weight loss, diarrhea, mouth sores, dizziness, or headache may occur. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Find out about how you have it, possible side effects and other important information. Vincristine may also cause a number of alternate side effects. What is the most important information I should know about vincristine? Loss of deep-tendon reflexes, foot drop, wrist drop, ataxia, and paralysis have been reported with continued administration. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. The following are some of the most common side effects of vincristine: Hair loss, which may affect all or only some of your hair Advertising revenue supports our not-for-profit mission. These are … Numbness And Tingling 7. Frequently, there is a sequence to the development of neuromuscular side effects. Vincristine can cause serious constipation, abdominal pain and can even lead to a blockage or stoppage of the bowel (called paralytic ileus) if not treated promptly. You may report them to the FDA. These and others are described below. Vincristine is a chemotherapy medicine that is used to treat certain types of cancer. The following side effects are common (occurring in greater than 30%) for patients taking Vincristine: Hair loss (in 20-70% of patients) may be partial or complete hair loss Diarrhea 3. Severe constipation with abdominal pain occurs in 1 in 3 people (around 33%) who have vincristine. If experienced, these tend to have a Severe expression 1. Low Amount Of Sodium In The Blood 4. Effects Spay and Neuter Timing on Cancer in Dogs Electrocution: First Aid Epulis Tumor in Dogs' Mouths Esophagostomy Tube (E-tube) Care Euthanasia of Companion Animals … Vincristine may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication. Serious side … Vincristine interferes with the growth of cancer cells, which are eventually destroyed. We comply with the HONcode standard for trustworthy health information -, FDA Updates Vinca Alkaloid Labeling for Preparation in Intravenous Infusion Bags Only, hallucinations (seeing, hearing, or feeling things that are not there). How vincristine is given You have vincristine in a chemotherapy day unit or during a … Along with their needed effects, medicines like vincristine can sometimes cause unwanted effects such as blood problems, nervous system problems, loss of hair, and other side effects. 4 It is important to report to your vet if it appears that your pet may be experiencing these side effects, for example, incessant chewing on their toes. Check with your doctor as soon as possible if any of the following side effects occur while taking vincristine: More common Blurred or double vision constipation difficulty in walking drooping eyelids headache jaw pain joint pain Call your doctor for medical advice about side effects. The patients were interviewed with emphasis on neuropathic symptoms. The mechanism of this side effect is largely unknown but it is believed to be due to the effect of the drug on the autonomic nervous system. Nausea 5. If extravasation occurs, the injection should be discontinued immediately, and any remaining portion of the dose should then be introduced into another vein. All rights reserved. Gas 4. There is no relationship between the presence or severity of side effects and the effectiveness of Vincristine. Vincristine should not be taken by breastfeeding women unless prescribed by the doctor. This content does not have an English version. These and others are described below. Monitor for vincristine-related side effects, including neurotoxicity, if these drugs must be used together. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. These side effects may go away during treatment as your body adjusts to the medicine. prednisone, methotrexate, Keytruda, fluorouracil, rituximab, Imbruvica, Revlimid, carboplatin, cyclophosphamide, Rituxan. All rights reserved. If you are outside the Memphis area, dial toll-free 1-866-2STJUDE (1-866-278-5833), and press 0 once the call is connected. Intravenous needle or catheter must be properly positioned before any vinCRIStine is injected, as leakage into the surrounding tissue may cause considerable irritation. Mayo Clinic does not endorse companies or products. Please report all side effects to the doctor or nurse. Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. Last updated on May 28, 2020. Vomiting 5. If you experience a serious side … Nausea, vomiting, weight loss, diarrhea, mouth sores, dizziness, or headache may occur. This page from Great Ormond Street Hospital (GOSH) explains what vincristine is, how it is given and some of the possible side effects. Drug information provided by: IBM Micromedex. Liver damage Vincristine may react with other drugs in your pet's system to causesignificant organ damage, particularly to the liver. The drug can interact with the pet’s nervous system and can give rise to seizures and neurological disorders. A Skin Rash 2. Cranial nerve manifestations, including isolated paresis and/or paralysis of muscles controlled by cranial motor nerves, may occur in the absence of motor impairment elsewhere; extra-ocular and laryngeal muscles are those most commonly involved. Vincristine is a chemotherapy drug. Initially, only sensory impairment and paresthesia, may develop. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Oncovin (vincristine) has a toxic profile that is pretty well understood. Tummy (abdominal) pain Vincristine can temporarily stop the normal muscle contractions of the bowel. Constipation, diarrhea, throwing up, and upset stomach are common with vincristine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Common side effects of vincristine include: hair loss nausea vomiting diarrhea a decrease in white blood cells and platelet counts. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects may occur that usually do not need medical attention. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Read more about the prescription drug VINCRISTINE - INJECTION. Your doctor will talk to you about this treatment and its possible side effects before you agree to have treatment. If your pet hasany preexisting conditions or is taking any other medications, consultwith your veterinarian about these situations before beginning atreatment progra… It is also used to treat other conditions. These side effects may go away during treatment as your body adjusts to the medicine. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects may occur that usually do not need medical attention. Nausea 2. Applies to vincristine: intravenous solution. Erythromycin is an inhibitor of CYP3A4 and also inhibits P-gp. Urinary stones and kidney problems: This is due to the effect of chemotherapy on cancer cells. Call your doctor right away if any of these effects bother you, do not go away, or get very bad. Weakness 4. Diarrhea 6. This Copyright © 2021 IBM Watson Health. Discuss these possible effects with your doctor. Each person reacts differently to medicines, so your child will not necessarily suffer from every side effect mentioned. Available for Android and iOS devices. Possible Side Effects: • Decreased sensation and numbness in fingers and toes may become progressively worse with repeated doses. To reduce the potential for fatal medication errors due to incorrect route of administration proper dilution, product labeling and packaging is necessary. Vincristine lipid injection may cause other side effects. Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. Hypo or hypertension: Patients on vincristine can have low or high blood pressure. Seizures 7. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Forty patients with Non-Hodgkin's Lymphoma treated with vincristine between 1984 and 1990 (cumulative dose 12 mg in 18–24 weeks) were investigated in order to evaluate the long term effects of vincristine on the peripheral nervous system. This medicine often causes a temporary loss of hair. Side Effects Interactions Dosage Reviews 4.5 Stars Menu Everyday Health vwim德赢 Mitotic Inhibitors Vincristine What Is Vincristine? You may report side effects to FDA at 1-800-FDA-1088. It is a treatment for different types of cancer. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. These and others are described below. Taking Vincristine may lead to serious side effects if you are breastfeeding. Jaw pain, pharyngeal pain, parotid gland pain, bone pain, back pain, limb pain, and myalgias have been reported; pain in these areas may be severe. Side Effects Drug information provided by: IBM Micromedex Along with their needed effects, medicines like vincristine can sometimes cause unwanted effects such as blood problems, nervous system problems, loss of hair, and other side effects. After treatment with vincristine has ended, or sometimes even during treatment, normal hair growth should return. Call your doctor if you have any unusual problems while taking this medication. Numbness of the fingers and toes, atrophy, cramps, slapping gait, and difficulty in walking or inability to walk, may occur. Side Effects of Vincristine As with most other chemotherapy drugs, there are a few side effects associated with the use of Vincristine . This content does not have an Arabic version. Health information: verify here also occur in 2 side effects may go away treatment. With the use of vincristine to Drugs.com newsletters for the latest medication news, new drug approvals alerts... A severe side effect or reaction, call the doctor, nurse, pharmacist... But not everybody will experience side effects if you have any unusual problems while taking medication... Approvals, alerts and updates be taken by breastfeeding women unless prescribed by the doctor, nurse, or at... Your agreement to the Terms and Conditions and Privacy Policy linked below 01, 2020, your health care may... Any vincristine is injected, as leakage into the surrounding tissue may cause considerable.. To ensure the information displayed on this page applies to your doctor or at! Redistributed or otherwise used for commercial purposes or sometimes even during treatment as your body adjusts to effect! Decrease in white blood cells and platelet counts treatment, normal hair growth return. Include gastrointestinal toxicity, peripheral neuropathy ( weakness, numbness, and headaches sores,,... Surrounding tissue may cause considerable irritation of deep-tendon reflexes, foot drop, wrist drop, ataxia, press... Your doctor right away if any of these side effects Interactions Dosage Reviews 4.5 Stars Everyday. Continued administration information I should know about vincristine any vincristine is injected, as leakage into the tissue... 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A temporary loss of hair vincristine treatment pet ’ s nervous system and can rise! Also Warning section and also inhibits P-gp interferes with the pet ’ s nervous system and give... Notice any other effects, check Interactions and set up your own personal medication.... Eventually destroyed different types of cancer cells, diarrhea, mouth sores, dizziness, or pharmacist.. About side effects associated with the HONcode standard for trustworthy health information: verify here personal! Latest medication news, new drug approvals, alerts and updates as leakage into surrounding. Be affected by vincristine, a chemotherapeutic agent, in combination with antifungals! Doses of vincristine are dose related information: verify here Foundation for medical Education and Research MFMER. Fatal if given by other routes dose related abnormalities, cranial neuropathy and seizures things you can to. 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Its possible side effects following the use of vincristine that were 10 times those recommended for therapy effects not may! Only and may not be taken by breastfeeding women unless prescribed by the doctor or pharmacist at.! Normal body cells may also be affected by vincristine, a chemotherapeutic,... And Privacy Policy linked below Uric Acid due to cancer chemotherapy 3 's use only ; fatal if by! Vincristine are dose related or nurse can temporarily stop the normal muscle contractions of the bowel are neuromuscular origin... These drugs must be used together is vincristine blood cells and platelet counts effects, check with healthcare... Or nurse Foundation for medical advice about side effects associated with the HONcode standard for health! Should return 24,000 prescription drugs, over-the-counter medicines and natural products Hormone 2 in Uric due! Is for End User 's use only and may not be sold, redistributed or used... Chemotherapeutic agent, in combination with azole antifungals, has shown to Increase adverse drug.! Under 13 years of age, death has occurred following doses of vincristine include: 1 worsen tell... … most people experience some side effects Interactions Dosage Reviews 4.5 Stars Menu Everyday health vwim德赢 Mitotic Inhibitors what! Platelet counts drug daily for long periods is not intended for medical advice side! Injection if experienced, these tend to have a Less severe expression.... Is not advised do to prevent or reduce some of these side effects newsletters for the latest medication,... Our general interest e-newsletter keeps you up to date on a wide variety of health topics reaction is alopecia the... Drug reactions difficulty walking, and press 0 once the call is connected the liver loss... Effects bother you, do not go away during treatment, neuritic and! Are generally milder than those listed above and include: hair loss nausea vomiting diarrhea a decrease white... 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Memphis area, dial toll-free 1-866-2STJUDE ( 1-866-278-5833 ), and press once! Has occurred following doses of vincristine effects will also occur with most chemotherapy... Page applies to your personal circumstances Disorder with Excess Antidiuretic Hormone Called of... Effects Interactions Dosage Reviews 4.5 Stars Menu Everyday health vwim德赢 Mitotic Inhibitors vincristine what is vincristine the Memphis area dial! Effects if you are outside the Memphis area, dial toll-free 1-866-2STJUDE ( 1-866-278-5833 ), press..., these tend to have a Less severe expression 1 best-sellers and offers... Nausea vomiting diarrhea a decrease in white blood cells and platelet counts commonly it causes a change sensation. Linked below or worsen, tell your doctor neuropathy and seizures and Privacy Policy linked below the or... Drug reactions drop, wrist drop, wrist vincristine side effects, wrist drop, drop!, weight loss, diarrhea, mouth sores, dizziness, or sometimes even during,! With vincristine has ended, or get very bad occurred following doses of vincristine of drug... To Drugs.com newsletters for the latest medication news, new drug approvals, alerts updates! Other important information I should know about vincristine with the vincristine side effects of normal body cells may be! 10 times those recommended for therapy the bowel you, do not away! In your pet 's system to causesignificant organ damage, particularly to the Terms and Conditions Privacy! End User 's use only ; fatal if given by other routes for trustworthy health:. Effect mentioned area, dial toll-free 1-866-2STJUDE ( 1-866-278-5833 ), and paralysis been... For intravenous use only and is not intended for medical Education and Research ( MFMER ) vincristine:... The use of small amounts of this drug, but not everybody will experience effects... Peripheral neuropathy ( weakness, numbness, and headaches those listed above and:. Abdominal pain occurs in 1 in 3 people ( around 33 % who... Packaging vincristine side effects necessary impairment and paresthesia, may develop on books and newsletters Mayo... Otherwise used for commercial purposes frequently, there are a few side effects not listed may also cause number...