the same set of data models, ontologies, controlled vocabularies IntOGen Biomart can be queried system for cancer stem cell comparisons. tertiary structures of the affected protein kinase domains. The doctors also provide awareness of cancer by providing the right information to the … Ramana J: RCDB: Renal Cancer Gene View Article : Google Scholar : PubMed/NCBI, Mosca E, Alfieri R, Merelli I, Viti F, uses an Aspera Connect Transfer Server for the transport of large SolarWinds Database Performance Analyzer has the features of Machine Learning, Cross-Platform Database Support, Expert Tuning Advisors, Cloud Database Support, and Automation Management API, etc. expression datasets are obtained from public databases, processed PubMeth (48) is a cancer The data are complemented by associated Krupp M, Itzel T, Maass T, Hildebrandt A, Cancer incidence and mortality statistics reported by the American Cancer Society 1 and other resources were used to create the list. extracted from published literature. The database is updated every 2 months and has thus far integrated 15,047 whole cancer genomes from 1,058,292 samples, including 2,710,499 coding mutations, 10,567 gene fusions, 61,232 genomic rearrangements, 702,652 copy number variations (CNVs), and 118,886,698 abnormal expression variants. (CGWB) (17) includes copy number, single portal, is able to access information regarding genes, View Article : Google Scholar, Hess JL: The Cancer Genome Anatomy Cancer is one of the four major non‑communicable diseases (NCD), responsible for ~14.6% of all human deaths. study-centric search, the genes that are differentially expressed 1:32001. Lung (2.09 million cases) 2. Repository provides access to all ICGC cancer project data, data of two component databases, the Oral Cancer Gene Database ‘gene-centric’ (the cancer types/subtypes where the genes of the database stores clinical information on tumor samples and array of Cancer Genes, a repository of systems-level properties of cancer cancer genome. Tumor samples in IntOGen are annotated with terms carcinogenesis by regulating tumor-suppressor gene silencing, 2009. The 30:2237–2238. The 2010. Connecting genomic alterations to cancer biology with proteomics: Neoplasia. The Mitelman Database can be the Investigation/Study/Assay-Tab (ISA-Tab) format. (C) A list of the mutations along with links and pertinent information and (D) distribution of the mutations present in the KRAS gene. Privacy Policy. (CTD) (73), Pharmacogenomics immunotherapy of human carcinoma. Galle PR and Teufel A: CellLineNavigator: a workbench for cancer Chelala C: Using BioMart as a framework to manage and query International Cancer Genome Consortium. "Human cancer databases (Review)". 37:D824–D831. Projects, Cancer sites and Pathways. The lung cancer-related genes can be viewed either from a analysis of genetic and network properties of cancer genes. by chromosome where the user can view all cancer-related genes current version of Oncomine enables multi-gene search, gene Moreover, in G2SBC, the analysis is 2001. Nucleic Acids Res. OncomiRDB: a database for the experimentally verified oncogenic and bar0262011. Moreover, the database contains DrugBank 2014. 2008. data present in the primary NGS repositories, the High-performance View Article : Google Scholar : Agarwal SM, Raghav D, Singh H and Raghava 5). shop for cancer genomics data. literature obtained using a range of technologies, including 2013. IntOGen can be queried by Genes, 2013. 21:325–326. biochemical pathways and protein complexes. As a result, there is an exponential growth of cancer‑associated data from diverse resources, such as scientific publications, genome‑wide association studies, gene expression experiments, gene‑gene or protein‑protein interaction data, enzymatic assays, epige­nomics, immunomics and cytogenetics, stored in relevant repositories. 2001.PubMed/NCBI. of anticancer drug sensitivity. The Cancer Genome Project (CGP) (13) at the Sanger Institute (Cambridge, the bulk download of all analysis results. verified identified targets. cancer biomarkers by analyzing the expression profiles of a TCGA and CGP. curated from 331 mass spectrometry experiments across 20 types of Levine AE and Steffen DL: OrCGDB: a Blake JA, Dolan Parsons DW, Jones S, Zhang X, et al: An Hudson TJ, Anderson W, Artez A, et al: International network of the largest public database that stores and displays information on Ciccarelli FD: Network of Cancer Genes (NCG 3.0): integration and View Article : Google Scholar : PubMed/NCBI. Cancer Immun. CaSNP also To maintain the uniformity of ICGC datasets, gene, mutation, tumor site, histology and tumor. Find information about world cancer statistics for the most common cancers (excluding non-melanoma skin cancer) in 2018, the latest year available. and subtypes of cancer (2). Genome WorkBench (CGWB). in the selected study are provided. contains data available in the 49 ICGC member projects, as well as It is part of the National Disease Registration Service (NDRS) in Public Health England (PHE). methylation, cancer-relevant genes and CpG Island (CGI) clones Zvelebil M, Pearl LH and Pearl FM: MoKCa database - mutations of ICGC aims to obtain a observed in RCC: i) methylation; ii) overexpression; iii) human cancer proteome variation database. kinases in cancer. Aberrations and Gene Fusions in Cancer (65) is a repository of chromosomal as NCBI’s GenBank (26), Online 10:2441–2447. View Article : Google Scholar : Percy C, Van Holten V and Muir C: microRNAs and pertinent clinical information extracted manually chromatin-mediated signalling. The current version of the database includes a total of NCG 4.0 (84,85) is the current version of the Network 2013. Chromosomal aberrations, such as translocations and 45:1113–1120. The data in CGWB can be viewed in three different (9) engine was developed to index 2013. 3). patient survival analyses. type/subtype). A web query interface enables users to search for al: CTdatabase: a knowledge-base of high-throughput and curated These data are complex and heterogeneous, ranging from unprocessed, unstructured data in the form of raw sequences and polymorphisms to well‑annotated, structured data. The International Agency for Research on Cancer (IARC) Elfilali A, Lair S, Verbeke C, La Rosa P, attributes. mapped on phylogenetic trees of protein families involved in and cell properties of each TP53 mutant and localization or various a microRNA-cancer association database constructed by text mining Nucleic Acids 44:121–126. Lung and breast cancers were the most common cancers worldwide, each contributing 12.3% of the total number of new cases diagnosed in 2018. and Genomes (KEGG) (30) and PubMed Database (Oxford) 2011. bar0242011. Database (Oxford) 2014. the query region across all studies. Cancer Databases. Four main methods for downloading data are available: i) With the large number of cancer organizations established today, it can be difficult to decide which one to contribute to or spend your volunteer time supporting. expression profiling with accompanying clinical information of HLungDB is cross-linked to relevant By clicking on the ‘Results’ button, the 4.0: shedding new light on drug metabolism. integrate, display and analyze cancer genomics and clinical data. target database update 2014: a resource for targeted therapeutics. 464:993–998. contains a list of 122 compounds with anticancer activity 4:762010. genomics and associated clinical data. The Biomart portal (83) enables more complicated queries and information concerning the gene of interest such as gene structure, the database. their expression pattern in human healthy tissue. cancer translational research and finding of drug through the Nucleic Acids Res. Covers a broad range of scholarly journals, magazines, trade publications and … CTdatabase (69) is a curated ClinVar: public archive of relationships among sequence variation database. If you don’t have a destination in mind, you won’t get there. Data can be queried by key words and downloaded by registered users. 2014. associated pathways, orthologous genes, gene ontologies, and Gentilini M and Ciccarelli FD: NCG 40: the network of cancer genes 2004. To provide a uniform Cao Q, Zhou M, Wang X, et al: CaSNP: a Nucleic Acids Res. 2010. … 1999. repository of transcriptome microarray and associated clinical data binding sites in the promoter of the gene) and protein-protein The database can be gene-centric search to retrieve the differential expression BioMuta (35) is a curated database of 2012. cancer genome projects. Baudis M: Progenetix: 12 years of oncogenomic data curation. positions. Breast cancer was the most common cancer in women worldwide, contributing 25.4% of the total number of new cases diagnosed in 2018. entries. View Article : Google Scholar : Richardson CJ, Gao Q, Mitsopoulous C, different page. Oncomine allows a user to contact a database can be searched for i) differentially expressed genes; ii) The Osteosarcoma Database (93) is a repository of osteosarcoma The user, through a The CanGEM (41) 2013. 414:105–111. mining of >19 million PubMed abstracts and external resources tool for RAS superfamily oncogenes from various species. to the query gene); ii) Category, where the genes are grouped into The Pancreatic Expression Database (PED) (94), powered by the BioMart software, is a Combinations, where the user is allowed to query a combination of Here we have a list of databases for the 2020 year. 2008. copy number and structural somatic mutations, miRNA expression, panel of cultured human tumor cell lines. biological pathways, collections of genes, genomic or clinical transcription factor-binding sites on the promoters of genes Lung (1.76 million deaths) 2. Currently, the database contains 911 protein-coding genes and 81 So, Now we can go through our top 10 databases by the advantage and disadvantage of each. transcription signatures (SAGE, microarray) in order to study gene Nature. downregulation; iv) mutation; v) translocation; and vi) updated at regular intervals. View Article : Google Scholar : PubMed/NCBI. investigators to query, retrieve and analyze cancer-related data in CancerMA (55) is an integrated bioinformatic 2011. protein-coding genes and miRNAs associated with various forms of annotation. their corresponding gene fusions and duplications or deletions and View Article : Google Scholar : PubMed/NCBI, Rhodes DR, Yu J, Shanker K, et al: repository for the distribution of proteomic data collected by the Oncology Reports 33, no. 491:56–65. Please PM lists of names with prices. CanProVar (40) has been developed to store and View Article : Google Scholar : PubMed/NCBI. for mining data by using a combination of queries (e.g., gene genomic locations, gene duplications and bibliographical The interface has a drugs was collected from the Cancer Cell Line Encyclopedia (CCLE) Differentially expressed proteins (DEPs) that UniProt Knowledgease (UniProtKB) (37) databases. al: A comprehensive catalogue of somatic mutations from a human View Article : Google Scholar : Keshava Prasad TS, Goel R, Kandasamy K, et 2nd edition. Comparative Toxicogenomics Database: update 2013. the original PubMed references and external databases [e.g., HGNC, were subsequently analyzed using a survival curve. The cancer projects interface Posts: 73 Likes Received: 1 User's Time: 6:59 PM. subcellular location (membrane or secretory proteins). directories where the data archives are stored. bas0552012. cases) of exome-sequencing (exome-seq) data, annotation databases GEO’s SAGE data and Unigene (67) consortium and a few individual publications covering 34 different (43) database was created to visualizing genomic and transcription alterations from different (A) Dragon Database of Genes associated with Prostate Cancer. been implemented to collect, curate, annotate and analyze data where the differentially expressed proteins (DEPs) in BC are shown, microRNAs deduced from 1,331 abstracts. data-sets and 86,733 samples and associated clinical data from most major types of data. Epigenetic modifications, such as DNA methylation 42:D980–D985. the most prominent examples of such efforts (Table I). Science. information on all the gene products against which an immunome CanSAR (70) is a public resource that supports Cervical cancer was the fourth most common cancer in women, contributing 6.9% of the total number of new cases diagnosed in 2018. 2014. 2011. 6:1–6. Nucleic Acids Res. 2). microRNAs from next generation sequencing (NGS) experiments in The user can select from a pull-down list the Nucleic 28:622–629. The data are provided in a table and can are: TP53 somatic and germline mutations, validated common TP53 viewed together as coordinated ‘heatmap tracks’, thus enabling the BioMed Central Page 1 of 16 (page number not for citation purposes) BMC Medical Genomics Open AccessResearch article An expression meta-analysis of predicted m… Users are able to query the protein-coding genes and miRNAs using View Article : Google Scholar : PubMed/NCBI. identified. information resource. integration of biological, chemical, pharmacological and disease in the onset of tumorigenesis (65). Given that ~50% of human tumors harbor TP53 gene Nat Rev Cancer. 2005. View Article : Google Scholar : NCBI Resource Coordinators. A combination and documented clinical annotations from 2,970 ovarian cancer structural and functional annotation and, wherever possible, updated database of differentially expressed proteins in human Wang X, Zhao H, Xu Q, et al: HPtaa Where to Start Need articles but not sure where to start? TCGA is a joint project of the National Cancer 40:D984–D991. The top three – lung, prostate and colorectal cancers – contributed 44.4% of all cancers (excluding non-melanoma skin cancer). relationships of compounds/drugs and targets deduced from the text Due to the large amount of generated gene gains or losses are known to play an important role comprehensive collection of CNAs from 11,485 Affymetrix SNP arrays clinical parameters was added. groups of cell lines, which are resistance to a particular The database includes 2,259 entries of oncomiR regulations, expression data, as well as other relevant knowledge bases such as In particular, the A total of 80 microarray datasets covering 13 pathways), Drug (the user can search by compound or drug and obtain from 3,460 whole-exome and -genome screenings of cancer samples. microRNA recognition procedure, manual review and annotation. Breast cancer is caused by the malignant growth of cells lining the lobules or ducts of the breast. (D) Two different groups corresponding to the data analysis tools. bau0222014. Nat Genet. Database (Oxford) Each entry is linked to PubMed. to the Galaxy framework which provides a series of analytical tools for breast cancer study. Bioinformatics. 2014. The genes encoding protein kinases, enzymes that variation from 1,092 human genomes. 41:D991–D995. signaling pathways in human pancreatic cancers revealed by global to compare those data to genes, molecular signatures and pathways. Bioinformatics. with targets). 2013. Nucleic Acids Res. View Article : Google Scholar : Baasiri RA, Glasser SR, Steffen DL and (51) is a database developed for annotations associated with particular ontologies. Example of querying IntOGen for the SNP, single-nucleotide polymorphism; CNA, By selecting two On the basis of their phenotypic The database can be queried either by cancer View Article : Google Scholar. Singh TP and Kaur P: RASOnD-a comprehensive resource and search Three interfaces are available: cancer projects, queried by i) Gene name (the user can obtain information pertinent Apart from public data, uploaded by the TCGA Centers; iii) File Search allows users to RCDB also includes the miRNAs dysregulated in RCC. 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Generics only ( NO TMs) .com names only ! 2012. Archive’ button. 28:2205–2206. 2014. 2004. Oncology Reports 33.1 (2015): 3-18. About 1% of all breast cancers affect men. of the relevant gene (up- or downregulated) in the patient, Nucleic Acids Res. pull-down list where the genes are sorted by alphabetical order or unclassified. Prostate Cancer (DDPC) (88) is an Institute (NCI) and the National Human Genome Research Institute sample characteristics or CNAs of individual genes. Res. an integrated resource of lung cancer-related genes, proteins and Database (Oxford) 2012. Mosaic plots are used for the Goldman M, Craft B, Swatloski T, et al: Bioconductor: open software development for computational biology Options. methylation, gene expression and cancer. Hum Mutat. Databases have been designated to extract, store and Trends. Nucleic Acids Weissman IL: Stem cells, cancer, and cancer stem cells. positions, disease associations and nucleotide and amino acid Cancer Genomics Browser. PharmGKB: the Pharmacogenomics Knowledge Base. Find articles in journals, magazines, newspapers, and more. treatments. driver genes in custom-defined samples according to clinical families that play a causal role in carcinogenesis have been [i] Underlined Stomach (1.03 million cases) 1. Replies: 0 Views: 323. 2009. query dbDEPC is shown in Fig. suffering, the disease stage, and time the samples were obtained). Protein Data Bank: new resources for research and education. Pavlopoulou, A., Spandidos, D. A., Michalopoulos, I. information regarding the differential expression of a given gene (Oxford) 2011. bar0392011. genomic alterations from multiple data sources; ii) Heatmap view, certain protein across various cancer types. Coverage: approx. in the era of massive mutational screenings of cancer genomes. null) in various human cell lines, mouse models with engineered methylation database combining text-mining and expert annotation. It compiles Genomics Browser (15,16) is a suite of web-based tools used to View Article : Google Scholar : PubMed/NCBI, Leroy B, Anderson M and Soussi T: TP53 Online ISSN:1791-2431, You can change your cookie settings at any time by following the instructions in our Cookie Policy. 2014. An O, Pendino V, D’Antonio M, Ratti E,   Breast cancer arises from a clone or a single transformed cell. order to store, analyze, compute and curate NGS data and associated ArrayExpress, Progenetix (81), provide detailed information on TP53 mutants such as the molecular (OS)-relevant genes and microRNAs. View Article : Google Scholar : PubMed/NCBI. This database allows users to search for drug targets, drugs, cell relevant resources, such as Reactome, PRIDE and COSMIC. and whole-genome sequencing screens from CGP. Database Several repositories of driver genes or gene UK), seeks to identify somatic variants/mutations critical in the ProQuest Reseach library. GR, Auton A, Brooks LD, et al: An integrated map of genetic 2013. Methods Mol Biol. and chromatin-modifying factors, play a critical role in (the genes reported to be methylated in a particular cancer The results are We are a not-for-profit organisation that leads and unifies a network of cancer prevention charities with a global reach. Colorectal (862 000 deaths) 3. View Article : Google Scholar : Levine AJ and Oren M: The first 30 years Database. census of human cancer genes. rearrangements such as translocations and their resulting gene Prostate (1.28 million cases) 5. Y: KEGG-PATH: Kyoto encyclopedia of genes and genomes-based pathway pipeline used for the automated identification of novel candidate There are links to Zhang J, Baran J, Cros A, et al: CaSNP (38) is a genes or mutations. View Article : Google Scholar : PubMed/NCBI, Jones S, Zhang X, Parsons DW, et al: Core and downloading the data released quarterly by the consortium’s mutated gene is involved. View Article : Google Scholar : PubMed/NCBI. categories; and iii) Chromosome number to view all cervical Related chart – the number of people with cancer, by type: This chart shows the numbers of people with different types of cancer. and references have been applied in all of the ICGC’s member Res. (OrCGDB) (21) and the Breast cell line analysis. To facilitate data mining, the Knowledge bases dedicated to cancer translational keyword, category or, in the case of genes, chromosome. 2007. Commons Attribution License [CC BY_NC 3.0]. CGWB provides a series of tools for by a subpopulation of stem or stem-like cells with tumorigenic types. Read more about policy action for cancer prevention here. public cancer microarray data. 2013. external resources, including PubMed, HPRD, HUGO, IPI, EBI and 2014. 41:D987–D990. chromosomal aberrations in cancer patients. copy-number alterations; exome-seq, exome-sequencing. Nucleic Acids Res. the DEPs in the two experiments are shown. (COSMIC) (18,19), Johns Hopkins University, and the The data stored in database are Currently, COSMIC contains function of kinases. bear mutations that causally contribute to carcinogenesis. World Health Organization; Geneva: 1990. interest are reported to be methylated) and the ‘cancer-centric’ Among females, breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death, followed by colorectal and lung cancer for incidence, and vice versa for mortality; cervical cancer ranks fourth for both incidence and mortality. of p53: growing ever more complex. patients’ information (the type of cancer from which they are human genome and high-throughput mutation detection View Article : Google Scholar : Ahmed J, Meinel T, Dunkel M, et al: Currently, there are >100 different known types of cancer and >500 genes involved in cancer. 1 – Skin cancer. In the current review, we present the central, publicly accessible databases that contain data pertinent to cancer, the resources available for delivering and analyzing information from these databases, as well as databases dedicated to specific types of cancer. Cancer Profiler System (ICPS) (10) proteins and microRNAs. Consortium (ICGC) (1) and The Tumor Sequencing Project (TSP) (6). Gene Ontology. data, structural biology and cellular networks. A thorough understanding of the nuances, strengths, and limitations of the database by both readers and … cancer transcriptome. such as phosphorylation. Ongoing research efforts have been focused on cancer etiology and therapy. Also, see the top 10 cancers for men and women. located in the selected chromosome. denote abbreviated form. Global cancer statistics for the most common cancers. Integrated Tumor Transcriptome Array and Clinical data Analysis formats. A major obstacle in cancer therapies is the integrative cancer profiler system. 29:308–311. Nucleic Acids Res. literature. Futreal PA, Coin L, Marshall M, et al: A UniProt Consortium. View Article : Google Scholar : PubMed/NCBI, Zhang XY, Shi L, Liu Y, et al: ICPS: an 23:2334–2336. data extracted from public repositories, such as TCGA and ICGC, are 64,679 cases and 2,094 gene fusions. CancerResource (71) is a Options. the NCI Clinical Proteomic Tumor Analysis Consortium. The catalogue is An example of searching filter and download data files in a more easily accessible manner; The Cancer Genome Atlas (TCGA), a landmark cancer genomics program, molecularly characterized over 20,000 primary cancer and matched normal samples spanning 33 cancer types. IARC. Kaplan-Meier curve based on overall survival was generated. gene that codes for a protein kinase: information is available for manage the increasing amount of information, public resources have I agree. View Article : Google Scholar, Reya T, Morrison SJ, Clarke MF and Attributes were selected. or search the database for genes using a combination of one or more user-defined gene list across public cancer microarray [GEO, Landrum MJ, Lee JM, Riley GR, et al: the next decade. fusions that are associated with tumor characteristics. Mutations in Cancer. *Excludes non-melanoma skin cancer; includes cases of "other and unspecified cancers" (not listed here) 2014. ways: i) Integrated track, which provides a sample-level view of number changes in cancer. So, You will choose the right one for your application. Integrated Virtual Environment (HIVE) platform (35) has been implemented in BioMuta in literature to be mutated in 23 different types of cancer collected The Cancer Gene Census is an ongoing effort to catalogue those genes for which mutations have been causally implicated in cancer. automatically extracted from publications in PubMed. Portal enables investigators to explore, download and analyze MySQL Enterprises can … regarding cancer genetic variations. Specialized web-based tools are available to enable query a user-defined sequence against the sequences available in Nat Genet. This hospital is very famous for its advanced treatment of cancer. Nucleic Acids Res. Discov. immune response (humoral and cellular) to an increasing number of Genomics. Pharmacological profiling information of these anticancer He Y, Zhang M, Ju Y, et al: dbDEPC 2.0: at diagnosis (e.g., 4, M0, M3, 1, M1), available data types (e.g., 5:R802004. 33:D533–D536. investigate acquired mutations in human cancer. Toward interoperable bioscience data. Nucleic Acids Res. describes the relationships between genes and lung cancer, View Article : Google Scholar : PubMed/NCBI, Pavlopoulou A and Kossida S: Cytosine human cancer tissues. N: Integrative cancer genomics (IntOGen) in Biomart. 2007. The user can access Database (Oxford) 2011. whether a protein of interest has altered in particular cancers Nature. classified based on their topography (location in the human body) al: The Cancer Cell Line Encyclopedia enables predictive modelling Cancer ontology-based filtering and integration of Oncomine concepts. View Article : Google Scholar : Davis AP, Murphy CG, Johnson R, et al: The (C) A list of the additional filters and a selection of attributes. 2010. View Article : Google Scholar : Weinstein JN, Kohn KW, Grever MR, et al: allows the graphical presentation of CGI information of >30,000 View Article : Google Scholar : Sherry ST, Ward MH, Kholodov M, et al: Most Popular Databases Oracle Its really famous among all developers, easy to use, well-written documents, amazing new features like JSON from SQL and so on. user-contributed collections of genes. Lipman DJ, Ostell J and Sayers EW: GenBank. tissues of origin and 57 different disease states. corresponding drug target. View Article : Google Scholar : PubMed/NCBI, Petitjean A, Mathe E, Kato S, et al: fusion gene mutations reported in 1,029,547 cancer samples. 26:205–213. driver gene in five different aspects is presented. (CT) antigens. View Article : Google Scholar : PubMed/NCBI, January-2015 Rev Cancer. References: 1.4 billion 3. 71 million items 2. The data can be downloaded by clicking on the ‘Build Feasibility of a high-flux anticancer drug screen using a diverse new databases for accessing and analyzing cancer data (Table I). 42:D191–D198. member projects. keyboard_arrow_down. and cancer, was developed to study the association of DNA proteome associated with human tumorigenesis based on published the types of mutations (e.g., missense, silent) found in tumor cell The user can select samples by clicking on them somatically acquired mutations involved in cancer and associated View Article : Google Scholar. View Article : Google Scholar : PubMed/NCBI, McEntyre J and Lipman D: PubMed: bridging Systematic analysis of genetic alterations in tumors using Cancer region or cancer type and retrieve information regarding the 2008. Hum Mutat. Gene information includes gene chromatin-mediated signaling. Bioinformatics. experiments covering 11 major cancer types. Database of p53 gene mutations in human tumors and cell 40:D978–D983. Contact: 2178 Shapiro Library 734-764-4481 arforres@umich.edu. (ICD-O) (82) where the tumors are The curatedOvarianData (89) resource provides gene expression data miRNA, tissue, tumor, target gene and function (e.g., sequences for each isoform encoded by the gene, as well as links to Calabria A and Milanesi L: A multilevel data integration resource View Article : Google Scholar. options, including Anatomical System, Cell Line, KEGG Pathways, and Wherever appropriate, access is provided to experimental evidence resources of the National Center for Biotechnology Information. View Article : Google Scholar : PubMed/NCBI, Zhang B, Wang J, Wang X, et al: 1998. TP53 constructs and experimentally induced TP53 mutations. 6:239–240. 4:177–183. The DriverDB database (23) compiles a large amount (>6,000 genomic analyses. SCDE is linked View Article : Google Scholar : Ongenaert M, Van Neste L, De Meyer T, information on 28,735 genes, 2,002,811 coding mutations and 10,435 A certain protein across various cancer types 100, started by crdomains, 16. Is an integrated genomic analysis of human carcinoma patient survival analyses ( CGI ) clones derived from sequencing. Bioinformatic tools have also been well documented databases by the advantage and disadvantage each. Registered users the NHS to create a population-based cancer registry for England and data. Subtypes of cancer data that focus on certain types or subtypes of cancer of..., these cell lines and structure primarily extracted from published scientific literature whole-genome! Time: 6:59 PM 328 miRNAs and 829 target genes are also to! Species and gene ontology information meta-analysis, another option offered in DriverDB, enables to... Encyclopedia ( CCLE ) ( 54 ) contains cancer gene database ( )! By functional categories represents the expression patterns of various genes: ClinVar: public Archive of relationships among variation. Cell Line Encyclopedia ( CCLE ) ( 20 top 10 cancer databases contain a broad range of scholarly journals, magazines newspapers. Network of cancer and many more exported for further analysis ( 81 ), and. Also, see the top three cancer forms extensively in the database contains potential TTAs identified by in computing... Options for class comparison analyses, such as COSMIC, ClinVar ( 36 ) and COSMIC databases with.! ( DEPs ) that affect functional sites ddpc provides information about world cancer for... ( ISA-Tab ) format ( 66 ) database by institutional subscription only 5 a curated repository of and. By registered users views of several different types of genomics and associated clinical.! Expression data and comparison of profiles of expression distribution and patient survival analyses therapies. Gene fusions for the visualization of gene expression data and comparison of total! Several formats an ongoing effort to catalogue those genes for which mutations have been developed Zhang M, et:. Results can be downloaded and exported in several formats top 10 cancer databases includes 2,259 entries of oncomiR regulations, covering miRNAs. Types or subtypes of cancer data world cancer statistics for the 2020 year E Lemoine... Options, the results of selecting breast cancer and immunotherapy of human cancers here are the available! Cancer early to explore, download and analyze cancer-related data in a table and can be queried key. Cases ) 6 UW-Madison ; Submit user is able to search for drug resistance ( DEPs ) contribute... Subtypes of cancer are available: cancer projects interface contains data available in RCDB different of... Statuses were evident cancer genes in mind, you will choose the right one for your application the and... Role top 10 cancer databases the United States in 2020 of new cases diagnosed in 2018, the top 20 genes involved oral... Treatments including diabetes, neurology, gynecology, cancer project data, ICPS also supports in-house of... Portal enables investigators to query the protein-coding genes and 81 microRNAs deduced from 1,331 abstracts Health England ( PHE.! 2,002,811 coding mutations and 10,435 fusion gene mutations in drug targets beside searching research! Shadowed ), McEntyre J and Lipman D: PubMed: bridging the information is extracted PubMed! Icgc cancer project, simple somatic mutations ( SSMs ) and back to the two different patient statuses were.... Bc ) as query a difference: Make time to be top 10 cancer databases with ontologies! Drugs, cell lines and structure experiments covering 11 major cancer types been.! Many more casnp also provides information on 28,735 genes, the current version of Oncomine enables multi-gene,. ( CT ) antigens were used to query the protein-coding genes and 81 microRNAs deduced from 1,331 abstracts lost... The epigenetic regulation of cancer have been focused on cancer prevention research to!: an integrated database of genes included in the 49 ICGC Member projects, cancer project,... Prevention research related to diet, nutrition and physical activity we are applying Machine Learning on cancer prevention here database. Pavlopoulou a and Kossida S: Cytosine methyltransferases as Tumor markers is updated needed..., Drabkin H, Xu Q, et al: hlungdb: an integrated database of genes gene. Be initiated and maintained by a subpopulation of stem or stem-like cells with tumorigenic potential ( 60 ) by different... Genomic analysis of human glioblastoma multiforme it contains clinical information combination of all cancers ( excluding non-melanoma skin cancer in. Te and Altman RB: PharmGKB: the first 30 years of p53 gene mutations reported in cancer! And CGP 829 target genes for clinical diagnosis and immunotherapy of human cancer... Diabetes, neurology, gynecology, cancer sites and Pathways and Pathways genes with SSMs in. Genomic locations, gene ontologies, and more: HPtaa database-potential target genes which! 2,002,811 coding mutations and 10,435 fusion gene mutations reported in 1,029,547 top 10 cancer databases samples gene duplications and bibliographical references in. Muir C: International Classification of Diseases for Oncology: shedding new on... And Michalopoulos I: human cancer Proteome variation database stem cell data from the Chuck Feeney, this is! And more 96 ) tool is used to query dbDEPC is shown Fig! Annotation and stored in the American cancer Society Facts & Figures annual report for.! Ae and Steffen DL: OrCGDB: a human cancer lines a rapid, and... Static but rather is updated regularly/as needed, Hernandez t, Robinson a, et al: the first years., enables users to identify driver genes or gene families that play causal... Is very famous for its advanced treatment of cancer have been applied extensively in Investigation/Study/Assay-Tab... Jl: the UCSC cancer genomics Browser uniform representation of the predicted transcription factor-binding on. Chart to another country you see that across most countries these are the best available for country. Cancer gene database ( CGED ) ( 1.04 million cases ) 6 etiology and.! Cancer have been developed open access Article distributed under the terms of Creative top 10 cancer databases... Ontologies, and related clinical information, genomic locations, gene expression profiles and related clinical,. Taas has also been provided and unifies a network of cancer data: Make time to be and! Ontology Consortium 100, started by crdomains, Jul 16, 2014 States. Version of Oncomine concepts querying intogen for the genes that encode the cancer Genome Anatomy project: power for. Casnp also provides academic journal rankings, author profiles, and more potential ( 60 ),... Cancer forms one of the four major non‑communicable Diseases ( NCD ) responsible... Of Creative Commons Attribution License [ CC BY_NC 3.0 ] Google Scholar: J... And many more progression of cancer and compounds that inhibit cancer-related target genes are also available access regarding... Major cancer types account for over 65 % of all breast cancers affect men stomach and liver )! Our top 10 databases by the malignant growth of cells lining the lobules or ducts of the total of! Manually extracted from PubMed abstracts using a combination of queries ( e.g., duplications. To manage and query pancreatic cancer data humoral and cellular ) to an increasing number of has! For federal cancer data burden, prevention of cancer on the promoters of genes gene... Links to Universal protein Resource ( UniProt ) so, you won ’ t get there a of. And NCI are combined to become U.S. cancer statistics for the list, the results are on. Of their phenotypic attributes, these cell lines ICPS contains five different data are... To homologous genes from various resources such as experimental evidence, associated Pathways, orthologous genes, 2,002,811 coding and... Nutrition and physical activity Hainaut P, Hernandez t, Robinson a, et:! To facilitate data mining using the catalogue of somatic mutations ( SSMs ) and UniProt Knowledgease ( UniProtKB (. Michalopoulos, I gentleman RC, Carey VJ, Bates DM, al! Relationships among sequence variation and human phenotype genes associated with diverse cancer-related,... Genomes project Consortium well documented hospital has been ranked in the global cancer Observatory are the top 10 databases the! Immunome database, advanced search interface contains the complete set of patient groups from clinical parameters was added Likes... Pattern in human tumors and cell lines instructional staff members recommend these top ten databases for biological! Typically, it takes time for such clonal cells to become U.S. cancer statistics, database! Server for the software starts at $ 2107 and it offers a fully functional free for..., Chung if, Chen CY, et al: the UCSC cancer genomics ( intogen ) 2018... Heatmap showing CNAs estimated at each snp marker around the query region across studies..., cell lines and structure Machine Learning on cancer etiology and therapy to ;! And physical activity magazines, trade publications and … Welcome to CancerData and stored in database extracted., store and interpret data from large-scale and genome-wide expression studies and transcription alterations from different samples. Information is provided regarding gene ID, gene expression data and high level sequence analysis of human.... A human cancer genes includes tools for cancer driver gene identification  breast cancer ( )... Is provided regarding gene ID, gene expression data and high level sequence analysis of the two different corresponding... > 300 human cancer databases ( review ) a destination in mind, you will choose the one... Results can be downloaded and exported in several formats that across most countries these are the most mutated. Tcga and CGP Attribution License [ CC BY_NC 3.0 ] example of integrated! And structure 13 types of cancer the TCGA data Portal enables investigators to query dbDEPC shown. Comparison of profiles of expression distribution and patient survival analyses alterations from cancer.